NAD+

🔬What Is NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every living cell and is fundamental to energy metabolism, DNA repair and cellular signalling. Endogenous NAD+ levels decline sharply with age — by middle age, tissue NAD+ can fall to roughly half of youthful levels, a process strongly implicated in mitochondrial decline, neurodegeneration and metabolic dysfunction. These oral NAD+ capsules deliver 500 mg of stabilised NAD+ per capsule (60 capsules per bottle), formulated for research into cellular energy, longevity pathways and sirtuin (SIRT1–SIRT7) activation.

📊Clinical Studies & Results

NAD+ is one of the most researched longevity compounds of the past decade. Landmark studies from Sinclair (Harvard), Imai (WashU) and Verdin (Buck Institute) have positioned NAD+ restoration as a central pillar of healthspan and metabolic-aging research.

• ▪Tissue NAD+ declines roughly 50% between age 40 and 60 in humans
• ▪NAD+ repletion restores mitochondrial function and reverses several markers of cellular aging in preclinical models
• ▪Activates SIRT1 and SIRT3 — pathways linked to caloric-restriction-mimicking effects, improved insulin sensitivity and DNA repair
• ▪Supports endothelial function, vascular health and exercise capacity in aging models
• ▪Emerging evidence for neuroprotective and cognitive benefits via NAD+/sirtuin signalling in the brain

NAD+ supplementation is one of the most evidence-backed interventions in modern longevity research. Oral NAD+ provides a non-invasive, daily way to study NAD+ restoration without IV infusions.

🏆Benefits

• Restores cellular NAD+ pools that decline with age
• Fuels mitochondrial ATP production and oxidative phosphorylation
• Activates the sirtuin family (SIRT1–SIRT7) — master regulators of longevity, DNA repair and metabolic health
• Supports PARP-mediated DNA damage repair
• Improves NAD+/NADH ratio — central to redox balance and metabolic flexibility
• Studied for improvements in cognitive sharpness, focus and mental clarity
• Convenient oral capsule — no IV infusions, no injections, no flushing

⚠️Possible Side Effects

• ▪Generally very well tolerated at oral research doses
• ▪Mild nausea or stomach discomfort possible on an empty stomach — take with food
• ▪Transient flushing or warmth reported by some subjects at high doses
• ▪Mild headache in early dosing
• ▪Rarely: insomnia if dosed late in the evening (NAD+ is energising — morning dosing preferred)

🎯Ideal For

• →Researchers studying cellular energy metabolism and mitochondrial function
• →Longevity and healthspan research models
• →Sirtuin pathway and DNA-repair studies
• →Neuroprotection and cognitive-aging investigations
• →Metabolic-health and insulin-sensitivity research